USP/EP Tablet Dissolution Testing Instrument
PTWS 130 is a 6-position, compact tablet dissolution testing instrument for solid dosage forms as described in USP chapter <711 /724> and EP section<2.9.3 /4> as well as the BP, DAB and Japanese Pharmacopeia section <15>. The S-Variant offers independent stirrer speed control for each of the six testing stations.
PTWS 130 tablet dissolution testing instrument with 6-position and PTWS 130 with ALGEX Magenta water bath preservative (on the right/bottom)
User Friendly Interface and User Management System
PTWS 130 is equipped with a wide 7-inch color touch screen, designed to enhance usability. The user interface incorporates rich graphical elements, smooth animations, and clear explanatory texts to guide users through every function. The flexible user management system allows for the inclusion of an unlimited number of users, ensuring secure and customized access. Additionally, the system supports an unlimited number of test methods, providing adaptability for a wide range of laboratory needs.
Regulatory Compliance and Audit Trail Features
The audit trail system records all events and changes within the instrument, providing a detailed account with both before and after information, fulfilling the regulatory requirements of 21 CFR Part 11. The audit trail can be filtered using criteria such as date & time, user, method and type of event.
Touch Screen Operation
All instrument interactions are carried out via a capacitive touchscreen interface, engineered to remain highly responsive even when operated with laboratory gloves. This design not only enhances user convenience but also supports strict hygiene standards in laboratory environments.
Instrument Design for Ease of Use and Reliability
The instrument head features a robust housing constructed from powder-coated stainless steel, ensuring exceptional durability and ease of cleaning. Integrated into the head is a 7-inch touch display, protected by a solid glass plate. This design not only offers a sleek appearance but also provides reliable protection for the display in demanding laboratory environments.
Quick Connector System
The Plexiglas water bath features a quick-connector system ensuring secure, leak-free attachment of the heater module to the water bath.
Convenient Water-Draining Design
The water bath is designed for convenient emptying and efficient cleaning. The tap connection has been enhanced for increased stability and repositioned to optimize drainage, facilitating more thorough removal of water. Additionally, both the cover and the water bath are removable, allowing for detailed and intensive cleaning when required.
Sturdy Water Bath Cover System
The water bath cover is constructed from protected Aluminum, offering dimensional stability. Dissolution vessels are inserted into rings fixed to the water bath cover and secured using centering rings equipped with a 3-way bayonet catch mechanism.
Convenient and Precise Electronic Lifter System
PTWS 130 is equipped with a centrally located electronic lifter. It offers the ability to program up to 16 working positions.
Heater and Circulation Pump Module Design
The pump and heater are combined into a single external module with a durable, powder-coated stainless-steel housing. The heater module's internal components have undergone significant advances, incorporating a fully self-contained heating system. This innovation removes the need for a control sensor inside the water bath, simplifying maintenance while ensuring precise and reliable temperature control.
Temperature Sensor and Probe
In addition, an external temperature probe is provided for monitoring the temperature within the vessels or the water bath. The heating system's safety is maintained through an array of internal temperature sensors positioned at both the inlet and outlet of the heater, as well as a resettable thermal cutoff switch.
MonoShaft Stirring Tools and Staggered Start
PTWS D630 uses the Pharma Test MonoShaft design with a main shaft and interchangeable tool heads. The shaft stays fixed in the instrument, keeping tool clearance consistent after initial installation. Each stirrer can be manually lifted for easy vessel access.
PTWS 130 also supports staggered start across its 6 positions, useful in manual mode.
PTWS 130S Variant with Individual Stirring Speed
This instrument version offers individual stirring speed control for each of the six testing stations by means of a dedicated stepper motor for each stirrer. This makes this model ideal for R&D purposes and dissolution method development.
Offline Sampling and Sample Preparation Options
Using PTWS 130 within an automated system offers the operator full access to the vessels before and at the end of a run as the complete drive head is lifted electronically. Sampling sequence timing is programmed using the menu system of the PTWS 130 instrument, while sampling volume and the optional media refilling process are programmed at the fraction collector. The system uses resident sampling probes fixed to the covers of the dissolution vessels. Each sampling probe holds a PP sinter filter (usually 5 or 10µ). When the tablets have been dropped into the dissolution vessels the automated test process starts. If the refilling option is used media refilling will start automatically after a sample has been withdrawn.
Connection to DSR-M Dissolution Sampling Robot and PTFC Fraction Collector
For offline automation PTWS 130 can be connected to the DSR-M dissolution sampling robot. DSR-M features the capability of sample dilution and media refilling. It offers excellent sampling and refilling accuracy via the fully integrated valve-less piston pump module.
Connection to PTFC Fraction Collector
Alternatively, the PTFC-2/8SP fraction collector with PT-SP syringe pumps can be used. No external software is necessary to control either of these systems.
ADS-L Closed Loop Online Automated Systems using Diode Array Spectrometer
For an online automated closed loop system the J&M TIDAS L UV/VIS spectrometer with an 8-position multi-cell-changer is the ideal choice. This system is controlled by the powerful WinDiss ARGUS Dissolution software running on the integrated PC of the TIDAS L spectrometer.
Dissolution Software WinDiss ARGUS
The WinDiss ARGUS Dissolution software is a scientific dissolution data management software for instrument control, data acquisition, data management, processing and reporting - designed by users for users. Whether you perform dissolution tests occasionally or several times each day WinDiss ARGUS Dissolution will make you more productive in running tests and analyzing results.
PT-Node Network Adapter for Printing and Data Transfer
PT-Node is an adapter that connects up to two Pharma Test instruments simultaneously to a network using a wired LAN connection. This way you can print test results from the instrument via your web browser on any local or network printer. Furthermore, it is possible to transfer the test results from the instruments to external systems in the same network. PT-Node supports PTWS 130.
| Parameter | Specification |
| Compliance | Fully USP <711/724>, EP <2.9.3/4>, BP, DAB and JP <15> compliant |
| Number of stirred vessels | 6 (3 by 2 arrangement) |
| Stirring tool design | MonoShaft™ stirrer design |
| Stirrer speed range | 25 - 250 RPM |
| Stirrer speed accuracy | ±2% of set speed, typically < 1% |
| Stirrer speed settings | PTWS 130D: one common speed setting for all stirrers
PTWS 130S: individual speed setting for each stirrer |
| Stirrer shaft wobble | Better than 0.2 mm total run out |
| Heating system | Heating and circulation pump module |
| Heating range | 25.0 - 45.0˚C |
| Heating accuracy | ± 0.2˚C inside the water bath |
| Display & date entry | 7?, 1024X600 pixel resolution color LCD touch screen, backlit |
| Audit trail | Integrated, logging all events and changes with before and after information, multi-level filtering |
| User management | Unlimited number of users with password and user rights |
| Working positions | 16 programmable stirrer immersion positions (paddle over disk, transdermal cylinder etc.) |
| Method management | Unlimited number of methods |
| Timer | Programmable sampling times, wake-up and sleeping mode, operation time information and timer count-down mode |
| Acoustic signal | Programmable acoustic signal for operator information |
| Calibration & PQ control | Built-in calibration programs with OQ/PQ interval warning |
| Printer support | External ticket printer or PT-Node network adapter |
| Interfaces | CAN port for remote control, RS-232 port to connect serial devices, I/O port for remote control of external instruments in automated systems, like DSR-M and PTFC |
| Instrument dimensions | Bath: approx. 75cm x 45cm x 75cm (width x depth x height) Heater: approx. 22cm x 32cm x 22cm (width x depth x height) |
| Net / gross weight | Approx. 75 / 130 kg |
| Certification | All components certified to USP / EP requirements |
| CE / EMC certification | All CE / EMC certification provided |
| Validation | All IQ & OQ documents included |
Features are subject to change due to ongoing development. We reserve the right to make technical changes without any prior notice.
In addition to the standard scope of supply, Pharma Test offers a broad range of accessories and options including:
